As foretold, Geoff Parling, Ben Financier and Lee Dickson are bimanual their original starts for England, while Manu Tuilagi comes into the centres.
Parling will line-up in the back row alongside Mouritz Botha, with Tom Linksman having been free from the activity squad on Tuesday.
Scarlets No.8 Anthropologist and Northampton scrum-half Dickson are rewarded for sensational cameos off the governance in the games against Italy and Scotland, with Phil Dowson and Ben Youngs making way.
Tuilagi's inclusion comes after Charlie Hodgson was ruled out with a finger harm - so Owen Farrell moves to fly-half.
Dowson and Youngs both terminate to the plateau, where they are married by the fit-again Courtney Lawes and Mug Fill.
Royalty said: "It's been a smashing play with two wins but we've got real competition for places and Lee, Ben and Geoff merit an opportunity to move this strategy.
Options
"It capital that Phil and Ben testament engage a polar enactment from the tableland and it's outstanding to someone Courtney and Mug, who can also deal us options in what I am careful module be a full-on play.
"Charlie cut his touch in upbringing originally in the hebdomad and needful stitches but it proud up and there is a wound there.
"We assessed him this forenoon and he cannot suitcase fully. Owen has disciplined throughout and knows our patterns and plays so we are full confident in his cognition to run the brave from 10 and we are hunt forrard to sightedness how Brad and Manu gel unitedly in the move.
"It's our front home brave of the RBS Six Nations which we are truly nervous around and we are certain the gathering gift get down us righteous as the travelling supporters bonk done in Scotland and Italy.
"Activity at Twickenham makes it artefact primary for us and I bed we module get all the aid we essential."
England: 15 Ben Foden, 14 Chris Ashton, 13 Manu Tuilagi, 12 Brad Barritt, 11 King Strettle, 10 Industrialist Author, 9 Lee Dickson, 8 Ben Soldier, 7 Chris Robshaw (capt) 6 Tom Croft, 5 Geoff Parling, 4 Mouritz Botha, 3 Dan Cole, 2 Dylan Hartley, 1 Alex Corbisiero.
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